CALIFORNIA
Study: Nasal tumors: Intra-arterial Chemotherapy and Radiotherapy to Treat Nasal Carcinoma
Location:  University of California-Davis-Davis, California
Contact: Dr. Culp for details at wculp@ucdavis.edu or (530) 752-1393

Summary:
The purpose of this study is to prospectively evaluate the response of nasal cancer to a combination of therapies
(chemotherapy and radiation therapy) in dogs.

Participation Requirements:
Dogs diagnosed with nasal tumors Initial Evaluation for Participation:

Procedures:
Dogs that are scheduled to receive radiation therapy for the treatment of nasal cancer can be enrolled in the study. Dogs will
be placed into a group receiving radiation therapy alone or with chemotherapy. Response to these treatments will be
assessed with CT scans (done before and after treatment). Benefits: The CT scans, chemotherapy administration, and part
of the radiation therapy will be paid for by the study.

Owner Responsibilities:
The owner will be responsible for providing follow-up information to the treating clinicians and returning the dog 4 weeks after
initiation of radiation therapy for a second CT evaluation (the first is performed prior to treatment).

WISCONSIN
Study: Stereotactic Radiation Therapy for Dogs with Nasal Tumors.
Location:  University of Wisconsin Veterinary Teaching Hospital, Madison, WI
Study Contact:  Noopur Desai at ndesai4@wisc.edu or (608) 263-7600; UW Veterinary Care Radiation Oncology Service at
608-263-7600
uwveterinarycare.wisc.edu/clinical-studies/oncology

For a study flyer, please click here.

Summary:
Nasal tumors are locally aggressive tumors of the nasal passages. Radiation therapy is the treatment of choice for dogs
affected by this cancer. At UW Veterinary Care, we have a TomoTherapy radiation delivery system which targets radiation to
the tumor while sparing the surrounding normal tissues from side effects. Stereotactic radiotherapy (SRT) is the use of this
very precise technology to deliver high doses of radiation in fewer treatments compared to conventional protocols. A
conventional radiation protocol for nasal tumors involves 10 radiation treatments, given as one treatment per day for 10
days. To take advantage of the extreme accuracy of stereotactic radiation therapy, we are investigating the efficacy of a
shorter protocol in which only 3 treatments are delivered over one week (on Monday, Wednesday and Friday). Compared to
the conventional protocol, a higher dose of radiation is used for each treatment to achieve a similarly effective total dose.
Potential benefits of stereotactic radiation therapy include fewer visits to the hospital for radiation treatments, fewer
anesthetic events, and a lower risk of short-term side effects. We will assess the safety of this new approach by monitoring
for any radiation-induced changes in the eye. Our hypothesis is that by delivering stereotactic radiation therapy, we will
safely decrease the number of treatments needed to effectively treat nasal tumors in dogs.

Eligibility: Dogs with a biopsy-confirmed diagnosis of cancer affecting the nasal cavity (carcinoma or sarcoma), stages I-III
may be eligible to participate in this study.

Exclusion:
Dogs with cribriform plate involvement and/or metastasis, or previous treatment for this cancer are not eligible.

Study Procedures:
Dogs will be evaluated at 2 & 4 weeks and 3 & 6 months post-radiotherapy to assess tumor response and side effects,
including ocular changes.

Financial Incentive:
Clients will receive financial compensation to cover the cost of their dog’s follow-up evaluations, including scheduled hospital
visits for a full examination including eye exams and a post-treatment CT scan.
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Last updated 2/19/2017
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